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Biotin-dPEG®₃-Lipoamide (QBD-10820)



Biotin-dPEG®3-lipoamide, product number QBD-10820, is a water-soluble PEGylation reagent designed to facilitate the biotinylation of a gold, silver, or other metal surface through a short (22 atoms, 27.7 Å) lipoic acid-functionalized single molecular weight, discrete PEG (dPEG®) spacer. The lipoic acid moiety forms dative bonds with gold, silver, and other metals, while the flexible, hydrophilic dPEG® spacer increases the hydrodynamic volume of the conjugate surface. This reduces or eliminates opsonization of the conjugate, contributing to a longer serum circulation time in vivo. Moreover, the water-soluble dPEG® linker improves the hydrophilicity of the biotin label, which is poorly soluble in water, reducing aggregation, precipitation, and non-specific interactions due to hydrophobicity. Potential applications for this product include pull-down assays, affinity chromatography, and biotin-based antibody pretargeting for radioimmunotherapy.


Unit Size100mg, 1000mg
Molecular Weight634.91; single compound
Chemical formulaC₂₈H₅₀N₄O₆S₃
Purity> 96%
SpacersdPEG® Spacer is 22 atoms and 27.7 Å
Typical solubility properties (for additional information contact Customer Support)DMAC, DMSO, acetonitrile, poorly soluble in methylene chloride. Insoluble in water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0), pp. 188-190, 458-497, 924-935.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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