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Azido-dPEG®12-acid (QBD-10513)



Azido-dPEG®12-acid, product number QBD-10513, is a click chemistry crosslinking reagent functionalized with an azide group and a propionic acid group on opposite ends of a linear spacer. A water-soluble, medium-length (40 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) spacer separates the two groups. The azide moiety reacts in copper(I)-catalyzed, ruthenium-catalyzed, and strain promoted azide-alkyne cycloadditions (CuAAC, RuAAC, and SPAAC, respectively). Alternatively, the azide functions as a masked amine. In this role, the carboxylic acid end of the molecule must couple with an amine to form an amide bond. The azide group is then reduced to a primary amine to permit crosslinking with a carboxylic acid group. The propionic acid moiety can be coupled to a primary or secondary amine by an acylation reaction.

The carboxylic acid group of Azido-dPEG®12-acid can be coupled directly to a free amine using EDC or some other carbodiimide. Also, forming the active ester of the acid using N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) before reacting with free amines is a useful course of action.


Unit Size100 mg, 1000 mg
Molecular Weight643.72; single compound
Chemical formulaC₂₇H₅₃N₃O₁₄
Purity> 98%
SpacersdPEG® Spacer is 40 atoms and 46.4 Å
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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