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Amino-dPEG®₁₂-acid (QBD-10287)



Amino-dPEG®12-acid, product number QBD-10287, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a polyethylene glycol spacer. The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®12-acid benefitted numerous applications, including peptide synthesis, surface modification, oligonucleotide sequencing, and small molecule modification.


Unit Size100 mg, 1000 mg
Molecular Weight617.72; single compound
Chemical formulaC₂₇H₅₅NO₁₄
Purity> 98%
SpacersdPEG® Spacer is 40 atoms and 46.5 Å
Typical solubility properties (for additional information contact Customer Support)Hot DMAC or DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Enzyme-Based Nanoscale Composites Composites for Use as Active Decontamination Surfaces. Cerasela Zoica Dinu, Guangyu Zhu, Shyam Sundhar Bale, Gaurav Anand, Philippa J. Reeder, Karl Sanford, Gregg Whited, Ravi S. Kane, and Jonathan S. Dordick. Advance Fuctional Materials. 2010, 20 (3), pp 392-398. February 8, 2010. DOI: 10.1002/adfm.200901388.

Immobilized molecular beacons: A new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events. Catherine Situma, Amanda J. Moehring, Mohamed A.F. Noor, Steven A. Soper. Elsevier, Analytical Biochemistry. 2007, 363 (1), pp 35-45, April 1, 2007. DOI: 10.1016/j.ab.2006.12.029.

Antistaphylococcal Nanocomposite Films Based on Enzyme-Nanotube Conjugates. Ravindra C. Pangule, Sarah J. Brooks, Cerasela Zoica Dinu, Shyam Sundhar Bale, Sharon L. Salmon, Guangyu Zhu, Dennis W. Metzgeter, Ravi S. Kane, and Jonathan S. Dordick. ACS Nano. 2010, 4 (7), pp 3993–4000. July 6, 2010. DOI: 10.1021/nn100932t.

Development of a sensitive surface Plasmon resonance immunosensor for detection of 2, 4-dinitrotoluene with a novel oligo (ethylene glycol)-based sensor surface. Kazutaka Nagatomo, Toshikazu Kawaguchi, Norio Miura, Kiyoshi Toko, Kiyoshi Matsumoto. Elsevier, Talanta. 2009, 79 (4), pp 1142-1148. September 15, 2009. DOI: 10.1016/j.talanta.2009.02.018.

Laccase-and chloroperoxidase-nanotube paint composites with bactericidal and sporicidal activity. Navdeep Grover, Indrakant V. Borkar, Cerasela Zoica Dinu, Ravi S. Kane, Jonathan S. Dordick. Enzyme and Microbial Technology. 2012, 50 (6-7) pp 271-279. May 10, 2012. DOI: 10.1016/j.enzmictec.2012.01.006.

Perhydrolase-nanotube paint composites with sporicidal and antiviral activity. Navdeep Grover, Marc P. Douaisi, Indrakant V. Borkar, Lillian Lee, Cerasela Zoica Dinu, Ravi S. Kane, Jonathan S. Dordick. Applied Microbiology and Biotechnology. 2013, 97 (19), pp 8813-8821. October 1, 2013. DOI: 10.1007/s00253-012-4573-3.

Bionanoconjugate-based composites for decontamination of nerve agents. Indrakant V.Borkar, Cerasela Zoica Dinu, Guangyu Zhu, Ravi S. Kane, and Jonathan S. Dordick. Biotechnology Progress. 2010, 26 (6) pp 1622-1628. September 21, 2010. DOI: 10.1002/btpr.498.

Sequence-Defined Oligoamide Drug Conjugates of Pretubulysin and Methotrexate for Folate Receptor Targeted Cancer Therapy. Ines Truebenbach, Jan Gorges, Jasmin Kuhn, Sarah Kern, Emanuele Baratti, Uli Kazmaier, Ernst Wagner, and Ulrich Lachelt. Macromolecular Bioscience. 2017, pp 1-12. March 30, 2017. DOI: 10.1002/mabi.201600520.

Applicable patents and legal notices are available at legal notices.

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