Lectins & Glycobiology Reagents

High-quality, purified lectins and other reagents for glycobiology and other applications

Lectins are a broad class of glycan binding proteins that have their origin as plant proteins known to agglutinate red blood cells. Since Lectins bind glycoconjugates in much the same way that antibodies bind antigens, researchers can use them to explore a myriad of biological structures and processes.

Specifically, Lectins can be used in glycobiology to:

  • Separate oligosaccharides, even those with identical sugar compositions
  • Discriminate between oligosaccharide structures
  • Isolate a specific glycoconjugate, cell, or virus from a mixture

Validation data from the National Center for Functional Glycomics (NCFG)

At Vector Laboratories, we employ a variety of procedures to purify our lectins and thereby ensure that they are of the highest quality. A selection of Vector Laboratories’ lectin products is also validated by the National Center for Functional Glycomics (NCFG) using the Consortium for Functional Glycomics (CFG) glycan arrays. The NCFG analyzes the glycan specificity of each lectin lot and makes the data available to the public on the NCFG website.

Formalin-fixed, paraffin-embedded mouse kidney stained with Fl-AAL. Mounted with VECTASHIELD HardSet with DAPI.
Colon (FFPE): Antigen retrieved with Antigen Unmasking Solution, stained with Cy5 Sambucus Nigra Lectin (SNA; fuchsia). DAPI counterstain (blue).

Explore Lectins & Glycobiology Reagents

Lectin screening kits provide a panel of lectins or lectin conjugates selected to provide a variety of sugar binding preferences. The smaller volume unit sizes in these kits are of the same high quality as individually offered lectin units.

All lectins manufactured by Vector Laboratories are extracted from a native plant source (i.e. seeds, bulbs, fruit etc.) and are not recombinant. Lectins are grouped based on their monsaccharide binding preferences.

Anti-lectin antibodies are offered in unconjugated or in biotinylated formats. In some applications, using biotinylated anti-lectins in conjunction with unlabeled lectins may provide greater sensitivity than using biotinylated lectins alone.

While the eluting solutions are primarily used in lectin agarose column and slurry preparations, inhibiting sugars, when combined with lectin solutions, have appeal as negative controls to prevent binding in IHC, IF, ELISA and blotting applications.


Resources

Lectins Application and Resource Guide

The Lectins Application and Resource Guide is a content rich educational booklet that provides
insight into how lectins are applied in biological sciences. With a focus on plant derived lectins, the guide showcases the flexibility and utilization of lectins and lectin conjugates in established lab applications. Download a copy of the guide >