CAS Number 1263047-17-1 | |
Molecular Weight 379.45; single compound | |
Chemical Formula C₁₆H₃₃N₃O₇ | |
Purity > 98% | |
Unit Size 100 mg, 1000 mg | |
Solubility Methylene chloride, DMAC or DMSO. | |
Spacers dPEG® Spacer is 18 atoms and 21.1 Å | |
Storage Instructions -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. | |
Shipping Instructions Ambient |
Amino-dPEG®₄-t-boc-hydrazide
Amino-dPEG®4-t-boc hydrazide, product number QBD-10041, is a useful molecular modification and bioconjugation reagent. The product has a free, primary amine on one end of a short (18 atoms, 21.1 Å) single molecular weight, discrete-chain-length polyethylene glycol (dPEG®) linker. The other end of this linker has a boc-protected hydrazide group. The free amine reacts with carboxylic acids and their active esters to form a stable amide bond. Following the removal of the Boc protecting group, the hydrazide can be reacted with an aldehyde (for example, formed from periodate oxidation of carbohydrates) at pH 5 – 7 to form a hydrazone bond. Hydrazone bonds are acid labile but otherwise stable, thus allowing the conjugate or supramolecular construct to degrade under acidic conditions such as in lysosomes or the acidic extracellular microenvironments at inflammation or tumor metastasis sites. The single molecular weight, discrete PEG (dPEG®) crossbridge is water-soluble and non-immunogenic, and it adds flexibility and increases the hydrodynamic volume of conjugates and supramolecular constructs that incorporate it.
Price range: $164.00 through $820.00
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