TCO-NHS Ester (equatorial)

TCO-NHS Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media. TCO-NHS ester is supplied as a single equatorial (major, rel-(1S-2S-5E-pR), ref 1 and 4) diastereomer. Specially formulated crystalline provides easy handling and extended shelf life.

Important Product Information:
TCO-NHS Ester is not recommended for labeling of proteins in aqueous buffers due to poor level of activation of labeled proteins (Rahim, M.K., et al., Bioconjugate Chem. 2015, 26, 352-360). TCO-PEG4-NHS Ester is well suited for protein and antibody labeling in aqueous buffers.

Price range: $183.00 through $2,648.00

Category: TCO Reagents

SKU	Unit Size	Price

Select a unit size:

How do I request a quote or bulk pricing?

SKU: CCT-1016

CAS Number 1191901-33-3
Molecular Weight 267.28
Appearance White to slightly grey crystalline
Chemical Formula C13H17NO5
Purity >95% (HPLC)
Unit Size 25 mg, 100 mg, 1000 mg
Solubility DMSO, DMF, DCM, THF, Chloroform
Storage Instructions -20°C. Desiccate
Shipping Conditions Dry ice
Shipping Instructions Dry ice

Selected References

Royzen, M., et al. (2008). A Photochemical Synthesis of Functionalized trans-Cyclooctenes Driven by Metal Complexation. J. AM. CHEM. SOC., 130: 3760-1. [PubMed]
Blackman, M.L., et al. (2008). Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity. J. AM. CHEM. SOC., 130: 13518-9. [PubMed]
Rahim, M.K., et al. (2015). Enhancing Reactivity for Bioorthogonal Pretargeting by Unmasking Antibody-Conjugated trans-Cyclooctenes. Bioconjugate Chem., 26: 352-60. [PubMed]
Rossin, R., et al. (2013). Highly Reactive trans-Cyclooctene Tags with Improved Stability for Diels−Alder Chemistry in Living Systems. Bioconjugate Chem., 24: 1210-7. [PubMed]