THPTA

THPTA (tris-hydroxypropyltriazolylmethylamine) is a water-soluble, very effective accelerating ligand for copper-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). In addition to greatly enhancing the rate of CuAAC, THPTA minimizes perturbations to the physiological state of the cells or organisms probed and allows for the effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation. The water-soluble THPTA ligand further simplifies click chemistry by allowing the entire reaction to be run in water.

Price range: $69.00 through $1,812.00

Category: Accelerating Ligands

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SKU: CCT-1010

CAS Number 760952-88-3
Molecular Weight 434.5
Appearance Off-white to grey solid
Chemical Formula C18H30N10O3
Purity >95% (HPLC)
Unit Size 100 mg, 500 mg, 1000 mg, 5 g
Solubility Water, DMSO, DMF, MeOH
Storage Instructions -20C
Shipping Conditions Ambient temperature
Shipping Instructions Ambient temperature

Selected References

Graham, A. J., et al. (2022). Extracellular Electron Transfer Enables Cellular Control of Cu(I)-Catalyzed Alkyne-Azide Cycloaddition. ACS Cent Sci., 8 (2), 246-257. [PubMed]
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Kang, D., et al. (2021). Bioorthogonal Retro-Cope Elimination Reaction of N, N-Dialkylhydroxylamines and Strained Alkynes. J Am Chem Soc., 143 (15), 5616-5621. [PubMed]
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Baskin, J. A., et al. (2021). A chemoproteomics approach to profile phospholipase D-derived phosphatidyl alcohol interactions. Cambridge: Cambridge Open Engage, This content is a preprint and has not been peer-reviewed. [ChemRxiv.]
Batrouni, A. G., et al. (2021). A palmitoylation code controls PI4KIIIα complex formation and PI(4,5)P₂ homeostasis at the plasma membrane bioRxiv, This content is a preprint and has not been peer-reviewed. [bioRxiv]
Feng, S., et al. (2021). Combining Metabolic Alkyne Labeling and Click Chemistry for Secretome Analysis of Serum-Containing Conditioned Medium^†. Chin. J. Chem., 39, 1843-1848. [Wiley Online Library]
Willems, L. I., et al. (2020). Tandem Bioorthogonal Labeling Uncovers Endogenous Cotranslationally O-GlcNAc Modified Nascent Proteins. J Am Chem Soc., 142 (37), 15729-15739. [PubMed]
Daughtry, J. L., et al. (2020). Clickable Galactose Analogues for Imaging Glycans in Developing Zebrafish. ACS Chem Biol., 15 (2), 318-324. [PubMed]
Tong, M., et al. (2020). Effective Method for Accurate and Sensitive Quantitation of Rapid Changes of Newly Synthesized Proteins. Anal. Chem., 92(14), 10048-57. [PubMed]