Biotin-PEG4-Alkyne (CCT-TA105)

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Description

Biotin-PEG4-Alkyne is non-cleavable, alkyne-activated biotinylation reagent that can be reacted with azides via a copper-catalyzed click reaction enabling efficient and specific conjugation of derivatized molecules in biological samples. The hydrophilic polyethylene glycol (PEG) spacer provides a long and flexible connection that minimizes steric hindrance involved with binding to avidin molecules.

Specifications

Unit Size5 mg, 25 mg, 100 mg, 1000 mg
Molecular weight457.58
Chemical compositionC21H35N3O6S
CAS1262681-31-1
SolubilityDMSO, DMF, MeOH
Purity>95% (HPLC)
AppearanceWhite to grey amorphous solid
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Selected References

  1. Feng, S., et al. (2021). Combining Metabolic Alkyne Labeling and Click Chemistry for Secretome Analysis of Serum-Containing Conditioned MediumChin. J. Chem.39, 1843-1848. [Wiley Online Library]
  2. Daughtry, J. L., et al. (2020). Clickable Galactose Analogues for Imaging Glycans in Developing Zebrafish. ACS Chem Biol.15 (2), 318-324. [PubMed]
  3. Simon P. Wisnovsky, et al. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. PNAS, 117 (41), 25293-25301. [PNAS]
  4. Bernardim, B., et al. (2020). Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling Bioconjugate Chem.31(6), 1604-10. [PubMed]
  5. Brito, I. L., et al. (2019). Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity. ACS Cent Sci.5 (5), 867-873. [PubMed]
  6. Zhang, C., et al. (2016). In vivo metabolic labeling of sialoglycans in the mouse brain by using a liposome-assisted bioorthogonal reporter strategy. Proc Natl Acad Sci U S A.113 (19), 5173-8. [PubMed]

Applicable patents and legal notices are available at legal notices.

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