Biotin-PEG4-Alkyne (CCT-TA105)


Biotin-PEG4-Alkyne is non-cleavable, alkyne-activated biotinylation reagent that can be reacted with azides via a copper-catalyzed click reaction enabling efficient and specific conjugation of derivatized molecules in biological samples. The hydrophilic polyethylene glycol (PEG) spacer provides a long and flexible connection that minimizes steric hindrance involved with binding to avidin molecules.


Unit Size5 mg, 25 mg, 100 mg, 1000 mg
Molecular weight457.58
Chemical compositionC21H35N3O6S
SolubilityDMSO, DMF, MeOH
Purity>95% (HPLC)
AppearanceWhite to grey amorphous solid
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Selected References

  1. Feng, S., et al. (2021). Combining Metabolic Alkyne Labeling and Click Chemistry for Secretome Analysis of Serum-Containing Conditioned MediumChin. J. Chem.39, 1843-1848. [Wiley Online Library]
  2. Daughtry, J. L., et al. (2020). Clickable Galactose Analogues for Imaging Glycans in Developing Zebrafish. ACS Chem Biol.15 (2), 318-324. [PubMed]
  3. Simon P. Wisnovsky, et al. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. PNAS, 117 (41), 25293-25301. [PNAS]
  4. Bernardim, B., et al. (2020). Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling Bioconjugate Chem.31(6), 1604-10. [PubMed]
  5. Brito, I. L., et al. (2019). Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity. ACS Cent Sci.5 (5), 867-873. [PubMed]
  6. Zhang, C., et al. (2016). In vivo metabolic labeling of sialoglycans in the mouse brain by using a liposome-assisted bioorthogonal reporter strategy. Proc Natl Acad Sci U S A.113 (19), 5173-8. [PubMed]

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