Biotin-PEG4-Alkyne

Biotin-PEG4-Alkyne is non-cleavable, alkyne-activated biotinylation reagent that can be reacted with azides via a copper-catalyzed click reaction enabling efficient and specific conjugation of derivatized molecules in biological samples. The hydrophilic polyethylene glycol (PEG) spacer provides a long and flexible connection that minimizes steric hindrance involved with binding to avidin molecules.

Price range: $122.00 through $1,843.00

Category: Terminal Alkyne Reagents

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SKU: CCT-TA105

CAS Number 1262681-31-1
Molecular Weight 457.58
Appearance White to grey amorphous solid
Chemical Formula C21H35N3O6S
Purity >95% (HPLC)
Unit Size 5 mg, 25 mg, 100 mg, 1000 mg
Solubility DMSO, DMF, MeOH
Storage Instructions -20°C. Desiccate
Shipping Conditions Ambient temperature
Shipping Instructions Ambient temperature

Selected References

Feng, S., et al. (2021). Combining Metabolic Alkyne Labeling and Click Chemistry for Secretome Analysis of Serum-Containing Conditioned Medium^†. Chin. J. Chem., 39, 1843-1848. [Wiley Online Library]
Daughtry, J. L., et al. (2020). Clickable Galactose Analogues for Imaging Glycans in Developing Zebrafish. ACS Chem Biol., 15 (2), 318-324. [PubMed]
Simon P. Wisnovsky, et al. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. PNAS, 117 (41), 25293-25301. [PNAS]
Bernardim, B., et al. (2020). Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling Bioconjugate Chem., 31(6), 1604-10. [PubMed]
Brito, I. L., et al. (2019). Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity. ACS Cent Sci., 5 (5), 867-873. [PubMed]
Zhang, C., et al. (2016). In vivo metabolic labeling of sialoglycans in the mouse brain by using a liposome-assisted bioorthogonal reporter strategy. Proc Natl Acad Sci U S A., 113 (19), 5173-8. [PubMed]