N-(4-pentynoyl)-galactosamine tetraacylated (Ac4GalNAl)

Ac4GalNAl is an unnatural alkyne-containing monosaccharide building block. The alkyne moiety can be used for modification though chemoselective ligation chemistries including CuAAC or various Pd-catalyzed coupling reactions. The acetyl groups increase solubility in many solvents and make handling of this building easier.

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SKU: CCT-1156
CAS Number
1658458-26-4
Molecular Weight
427.4
Appearance
White to grey amorphous solid
Chemical Formula
C19H25NO10
Purity
>90%
Unit Size
5 mg, 25 mg, 100 mg
Solubility
DMSO, DMF, DCM, THF, Chloroform
Storage Instructions
-20°C.
Shipping Conditions
Ambient temperature
Shipping Instructions
Ambient temperature
Selected References
  1. Wood, T. M., et al. (2021). Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase. ACS Chem. Biol., [PubMed]
  2. Daughtry, J. L., et al. (2020). Clickable Galactose Analogues for Imaging Glycans in Developing Zebrafish. ACS Chem Biol., 15 (2), 318-324. [PubMed]