N-azidoacetylgalactosamine-tetraacylated (Ac4GalNAz) (CCT-1086)

Description

The unnatural azido-containing monosaccharide building block. The azide moiety can be used for modification though chemoselective ligation chemistries including CuAAC, Cu-free click reaction or Staudinger ligation. The acetyl groups increase solubility in many solvents and make handling of this reagent easier.

Specifications

Unit Size5 mg, 25 mg, 100 mg
Molecular weight430.37
Chemical compositionC16H22N4O10
CAS653600-56-7
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>90%
AppearanceWhite to grey amorphous solid
Storage Conditions-20°C.
Shipping ConditionsAmbient temperature

Selected References

  1. Simon P. Wisnovsky, et al. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. PNAS, 117 (41), 25293-25301. [PNAS]
  2. Ranzinger, R., et al. (2020). Mass Spectrometric Method for the Unambiguous Profiling of Cellular Dynamic Glycosylation. ACS Chem. Biol., 15, 10, 2692-2701. [ACSPublications]
  3. Suttapitugsakul, S., et al. (2019). Surface Glycoproteomic Analysis Reveals That Both Unique and Differential Expression of Surface Glycoproteins Determine the Cell Type. Anal. Chem., 91(10), 6934–42. [PubMed]
 

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