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NEUROBIOTIN-Plus Tracer is a biotin label that is impervious to cleavage and breakdown by biotinidase. It is used for visualizing neural architecture and for the identification of gap junction coupling
| Unit Size | 5 mg |
|---|---|
| Recommended Storage | 2-8 °C (desiccated). Once in solution, store frozen. This product does not contain an antimicrobial agent. |
| Recommended Usage | Fixable with formaldehyde or glutaraldehyde |
| Solution | 10% solutions can be made in water, buffers, 1 M KCl, 1 M NaCl, or dimethylsulfoxide. |
| Molecular Weight | 358 g/mol |
| Neuronal Tracer - Direction of Transport | Anterograde/Retrograde |
| Detection Method | Avidin(Streptavidin)/Biotin Method, Chromogenic, Fluorescence |
Investigators have identified rapid degradation of injected tracers such as biocytin due to the presence of biotinidase activity in brain tissue*. This loss of stability of the tracer significantly reduces the viable postinjection period and may compromise complete detection of a neural network. NEUROBIOTIN-Plus was designed to be impervious to cleavage and breakdown by biotinidase. This newly synthesized biotin-containing compound contains fixable amine groups, is highly soluble and has a low molecular weight. These characteristics make it an ideal candidate for experiments requiring long postinjection survival times and optimal uptake along the entire neural tract.
NEUROBIOTIN-Plus shares the same key advantages of NEUROBIOTIN Tracer over biocytin and other neuronal labels:
NEUROBIOTIN-Plus can be detected using avidin or streptavidin systems with either chromogenic or fluorescence visualization methods.
*Mishra, A. et al (2010) ACS Chem. Neurosci. 1:129-138.
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