Amino-dPEG®₄-t-butyl ester

Amino-dPEG®4–t-butyl ester, product number QBD-10221, is a PEG modification reagent consisting of a primary amino group and the tert-butyl ester of a propionic acid group on either end of a monodisperse PEG4 spacer. The terminal amine reacts with carboxylates to form amide bonds and with aldehydes and ketones to form semi-labile, reducible Schiff bases. Trifluoroacetic acid (TFA) effectively removes the tert-butyl ester protecting group, thus freeing the propionic acid for reaction with amines or formation of an active ester with N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP).

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SKU: QBD-10221
CAS Number
581065-95-4
Molecular Weight
321.41; single compound
Chemical Formula
C₁₅H₃₁NO₆
Purity
> 98%
Unit Size
100 mg, 1000 mg
Solubility
Methylene chloride, DMAC, or DMSO.
Spacers
dPEG® Spacer is 16 atoms and 18.0 Å
Storage Instructions
-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.
Shipping Instructions
Ambient