Alkyne Sphinganine (CCT-1452)


Alkyne Sphinganine a metabolic labeling reagent that contains a terminal alkyne moiety that allows for the subsequent tagging of protein−lipid complexes by click chemistry. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as ‘click chemistry’, in the presence of a copper (Cu)-containing catalyst allowing for the visualization and proteomic profiling of protein−sphingolipid complexes in living cells.


Unit Size1 mg, 5 mg, 25 mg
Molecular weight297.46
Chemical compositionC18H35NO2
SolubilityDMSO, DMF
Purity>95% (H NMR)
AppearanceWhite crystalline
Storage Conditions-20°C.
Shipping ConditionsAmbient temperature

Selected References

  1. Gaebler A., et al. (2016). A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins. J. Lipid Res.57, 1934-47. [PubMed]
  2. Gaebler A., et al. (2013). Alkyne lipids as substrates for click chemistry-based in vitro enzymatic assays. J. Lipid Res.54, 2282-90. [PubMed]
  3. Lee, M.T., et al. (2020). Dietary sphinganine is selectively assimilated by members of themammaliangut microbiome. J Lipid Res . [PubMed]

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