9AzNue5Ac

Metabolic labeling of glycans with unnatural sialic acid analogues has emerged as an invaluable tool for studying sialic acid biology. It has been showed that 9-azido-9-deoxy-N-acetylneuraminic acid (9AzNeu5Ac), a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide, could be metabolized and incorporated into sialoglycans in living cells and mice. The incorporated sialic acid analogue, 9AzNeu5Ac, enable visualization the cell-surface sialoglycans and glycoproteomic profiling by click-labeling with fluorophores and affinity tags, respectively.

Price range: $166.00 through $745.00

Category: Glycosylation

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SKU: CCT-1534

CAS Number 76487-51-9
Molecular Weight 334.28
Appearance Slightly grey amorphous solid
Chemical Formula C11H18N4O8
Purity ≥95% (HPLC)
Unit Size 5 mg, 25 mg, 100 mg
Solubility DMSO, DMF, DCM, THF, Chloroform
Storage Instructions -20°C.
Shipping Conditions Ambient temperature
Shipping Instructions Ambient temperature

Selected References

Cheng, B., et al. (2019). 9-Azido Analogues of Three Sialic Acid Forms for Metabolic Remodeling of Cell-Surface Sialoglycans. ACS Chem Biol. 14(10), 2141-7 [PubMed]
Zhang, C., et al. (2016). In vivo metabolic labeling of sialoglycans in the mouse brain by using a liposome-assisted bioorthogonal reporter strategy. Proc Natl Acad Sci U S A., 113 (19), 5173-8. [PubMed]
Xie, R., et al. (2012). Cell-selective metabolic glycan labeling based on ligand-targeted liposomes. J. Am. Chem. Soc., 134(24), 9914-7. [ACSPublications]