Tetrazine-NHS Ester

Tetrazine-NHS Ester demonstrates exceptionally fast cycloaddition kinetics (up to 30 000 M-1 s-1) with trans-cyclooctene (TCO) as the dienophile, the fastest kinetics ever reported for any bioorthogonal reaction. The chemical stability tetrazines is substantially lower compared to Methyltetrazines, which requires more careful selection of reagents and conditions for chemical transformation, however it is in acceptable range for many applications.

This product is not recommended for labeling of proteins or any other biopolymers in aqueous buffers due to poor aqueous solubility.

Price range: $183.00 through $1,865.00

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SKU: CCT-1127
CAS Number
1616668-55-3
Molecular Weight
313.27
Appearance
Red crystalline
Chemical Formula
C14H11N5O4
Purity
>95% (HPLC)
Unit Size
25 mg, 100 mg, 500 mg, 1000 mg
Solubility
DMSO, DMF, DCM, THF, Chloroform
Storage Instructions
-20°C. Desiccate
Shipping Conditions
Ambient temperature
Shipping Instructions
Ambient temperature
Selected References
  1. Sun, N., et al. (2020). Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring. Nat Commund., 11, 4489. [PubMed]