t-boc-N-EDA, product number QBD-10226, CAS number 57260-73-8, is the boc-protected form of ethylenediamine. It is not a dPEG® product. However, it can be useful in bioconjugation reactions where an exceptionally short, monoprotected, homobifunctional crosslinker is needed. The free primary amine reacts with activated esters of carboxylic acids (for example, the N-hydroxysuccinimidyl ester, also known as NHS) to form amide bonds. Treatment of the resulting conjugate with acid (for example, TFA) removes the boc protecting group from the protected amine, leaving a primary amine that is free to react.
| Unit Size | 1000 mg |
|---|---|
| Molecular Weight | 160.21; single compound |
| Chemical formula | C₁₅H₃₂N₂O₅ |
| CAS | 57260-73-8 |
| Purity | > 98% |
| Spacers | dPEG® Spacer is 4 atoms and 3.8 Å |
| Shipping | Ambient |
| Typical solubility properties (for additional information contact Customer Support) | Methylene chloride, DMAC or DMSO. |
| Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
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