MAL-dPEG®4-(m-dPEG®24)3, product number QBD-10456, is a sulfhydryl-reactive, branched polyethylene glycol (PEG) product built around a tris core that is useful for modifying surfaces and biomolecules containing free thiols. Vector Laboratories, Inc. manufactures this monodispersed PEG product with a single molecular weight and discrete chain length and sells it under the dPEG® tradename. MAL-dPEG®4-(m-dPEG®24)3 increases the hydrophilicity of conjugated molecules; reduces non-specific, hydrophobic interactions; and decreases or eliminates the antigenicity of conjugates. Also, because it is a single molecule, the analysis of conjugates made with MAL-dPEG®4-(m-dPEG®24)3 is simplified compared to the analysis of conjugates prepared with traditional dispersed PEG products.
| Unit Size | 100 mg, 1000 mg |
|---|---|
| Molecular Weight | 3946.64; single compound |
| Chemical formula | C₁₇₈H₃₄₆N₆O₈₆ |
| CAS | 1334178-05-0 |
| Purity | > 96% |
| Spacers | dPEG® Spacer is 103 atoms and 108.3 Å, Avg. |
| Shipping | Ambient |
| Typical solubility properties (for additional information contact Customer Support) | Methylene chloride, DMAC or DMSO. |
| Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Chapter 1, p. 30.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
Applicable patents and legal notices are available at legal notices.
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