m-dPEG®₈-DSPE

m-dPEG®8-DSPE, product number QBD-11024, modifies the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) with a short (26 atoms, 29.8 Å), methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) spacer. This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The m-dPEG®8 spacer offers protection from opsonization comparable to the traditional polymer mPEG2000, while the smaller spacer size compared to mPEG2000 allows for more efficient uptake into cells. The methyl-capped dPEG® spacer has a neutral charge.

Vector Laboratories’ dPEG® products are highly pure single molecular weight compounds with a discrete chain length. Traditional PEG compounds used to coat liposomes and micelles consist of an intractable mixture of different chain lengths and molecular weights. The non-uniform polymeric mixture leads to irreproducible purity profiles, unlike dPEG® compounds.

Price range: $137.00 through $273.00

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SKU: QBD-11024
CAS Number
N/A
Molecular Weight
1142.52; single compound
Chemical Formula
C₅₉H₁₁₆NO₁₇P
Purity
> 96%
Unit Size
25 mg, 100mg
Solubility
Methylene Chloride.
Spacers
dPEG® Spacer is 26 atoms and 29.8 Å, avg.
Storage Instructions
-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.
Shipping Instructions
Ambient