CAS Number 88504-24-9 | |
Molecular Weight 1239.44; single compound | |
Chemical Formula C₅₆H₁₀₆N₂O₂₇ | |
Purity > 98% | |
Unit Size 100 mg, 1000 mg | |
Solubility Methylene chloride, Acetonitrile, DMAC or DMSO. | |
Spacers dPEG® Spacer is 80 atoms and 50.7 Å | |
Storage Instructions -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. | |
Shipping Instructions Ambient |
m-dPEG®₂₄-MAL
m-dPEG®24-MAL, product number QBD-10319, is a sulfhydryl-reactive, single molecular weight, with a discrete chain length PEG (dPEG®). This product modifies surfaces and biomolecules with free thiol groups through the maleimide reactive group. The non-immunogenic, methyl-terminated dPEG® chain has no charge but adds water solubility and hydrodynamic volume to molecules to which it is conjugated.
The reaction of the maleimide end of m-dPEG®24-MAL, product number QBD-10319, with a sulfhydryl proceeds best at pH 6.5 – 7.5. Conduct the conjugation at the lowest reasonable pH within this range. Above pH 7.5, free amines compete with free thiols at the maleimide reaction site, which creates confusing results. Moreover, at higher pH values, the maleimide ring may open to form unreactive maleamic acid.
Published uses for m-dPEG®24-MAL include the following:
modifying surface-accessible free thiols on enzymes to probe enzymatic function;
developing a virus-based drug delivery system; and,
developing probes of cellular redox reactions.
Price range: $315.00 through $973.00
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