DBCO Maleimide (CCT-A108)

Description

DBCO Maleimide enables simple and efficient incorporation of DBCO moiety onto cysteine-containing peptides or other thiol-containing molecules. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form stable thioether bonds.

This product is not recommended for labeling of proteins or any other biopolymers in aqueous buffers due to poor aqueous solubility.

Specifications

Unit Size25mg, 100 mg, 1000 mg
Molecular weight427.75
Chemical compositionC25H21N3O4
CAS1395786-30-7
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceSlightly grey to slightly orange solid
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Selected References

  1. Kiseleva, R., et al. (2020). MBivalent engagement of endothelial surface antigens is critical to prolonged surface targeting and protein delivery in vivo. FASEB Jornal, 34, 9, 11577-93. [FASEB]

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