DBCO-dPEG®24-amido-dPEG®24-DSPE is a 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) group functionalized with a long (152 atoms, 180.0 Å) single molecular weight, discrete PEG (dPEG®) spacer. The spacer consists of two dPEG®24 linkers joined by an amide bond, making it effectively a dPEG®48 spacer with a molecular weight slightly greater than 2,000 Daltons (that is, equivalent to a PEG2000 spacer). The distal end of the dPEG® spacer is functionalized with a dibenzylcycloctyne (DBCO) group for strain-promoted, azide-alkyne cylcoaddition (SPAAC) reaction, also known as copper-free click chemistry. The DBCO can be functionalized with a suitable cytotoxic or imaging payload. The DSPE group is designed for insertion into liposomes, micelles, or other lipid nanoparticles.
| Unit Size | 25 mg, 100 mg |
|---|---|
| Molecular Weight | 3306.083; single compound |
| Chemical formula | C₁₆₃H₂₉₉N₄O₆₀P |
| CAS | N/A |
| Purity | > 95% |
| Spacers | dPEG® Spacer is 152 atoms and 180.0 Å |
| Shipping | Ambient |
| Typical solubility properties (for additional information contact Customer Support) | Methylene Chloride, Acetonitrile, DMSO, DMF, or Chloroform |
| Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
Applicable patents and legal notices are available at legal notices.
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