DBCO Amine

DBCO Amine is a simple DBCO-containing building block used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond.

DBCO reagents, also know as ADIBO or DIBAC are the most commonly used substrates for copper-free click reaction. DBCO compounds react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Price range: $122.00 through $4,555.00

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SKU: CCT-A103
CAS Number
1255942-06-3
Molecular Weight
276.33
Appearance
Slightly grey to slightly orange solid
Chemical Formula
C18H16N2O
Purity
>95% (HPLC)
Unit Size
25mg, 100mg, 1000mg, 5g
Solubility
DMSO, DMF, DCM, THF, Chloroform
Storage Instructions
-20°C. Desiccate
Shipping Conditions
Ambient temperature
Shipping Instructions
Ambient temperature
Selected References
  1. Davis, G. J., et al. (2021). Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization. Bioconjugate Chem., 32 (2), 254-258. [PubMed]
  2. Kakwere, K., et al. (2018). Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides. Biomater. Sci., 6, 5850-8. [PubMed]
  3. Zeng D., et al. (2012). 64Cu Core-labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Med Chem Lett., 6(6), 5209–19. [PubMed]
  4. Bouvet, V., et al. (2011). Copper-free click chemistry with the short-lived positron emitter fluorine-18. Org Biomol Chem., 9(21), 7393-9. [PubMed]
  5. Carpenter, R.D., et al. (2011). Copper-Free Click for PET: Rapid 1,3-Dipolar Cycloadditions with a Fluorine-18 Cyclooctyne. ACS Med Chem Lett., 2(12), 885-9. [PubMed]
  6. Arumugam S., et al. (2011). [18F]azadibenzocyclooctyne ([18F]ADIBO): a biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg Med Chem Lett., 21(23), 6987-91. [PubMed]