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Amino-dPEG®₂-t-butyl ester (QBD-10264)



Amino-dPEG®2–t-butyl ester, product number QBD-10264, is a monodispersed polyethylene glycol (PEG) crosslinker containing a primary amino group and a tert-butyl ester-protected propionic acid group. The terminal amine reacts with carboxylates to form amide bonds and with aldehydes and ketones to form semi-labile, reducible Schiff bases. The tert-butyl ester protecting group removes easily with trifluoroacetic acid (TFA), leaving the propionic acid free to react with amines or form an active ester with N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP). This compound is useful as a building block in supramolecular construction, a peptide modification reagent, a surface coating for biomolecules and inorganic/metal surfaces, or for protein modification.


Unit Size100 mg, 1000 mg
Molecular Weight233.30; single compound
Chemical formulaC₁₁H₂₃NO₄
Purity> 98%
SpacersdPEG® Spacer is 10 atoms and 10.9 Å
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC, or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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