DBCO Reagents

Payload Delivery Linkers and Modifiers | Uniform mPEG Modifiers: DBCO Reagents

DBCO reagents in Uniform mPEG (methoxy polyethylene glycol) Modifiers are PEG derivatives functionalized with dibenzocyclooctyne (DBCO) groups, enabling copper-free Click Chemistry via strain-promoted alkyne–azide cycloaddition (SPAAC).

These reagents allow for fast, selective, and bioorthogonal conjugation to azide-labeled biomolecules under mild, catalyst-free conditions. The uniform mPEG structure imparts enhanced solubility, reduced immunogenicity, and improved pharmacokinetics, making these reagents ideal for drug delivery, imaging, and therapeutic bioconjugation.