With applications ranging from drug targeting to genome sequencing, bioconjugation provides tools for more effective imaging and drug discovery methods. Join us as we explore the possibilities in this article.
Hypersialylation of glycans is one of the key drivers in cell differentiation in cancer, including pancreatic ductal adenocarcinoma (PDAC) cells. In this article, we review a study investigating how this mechanism led to the differentiation of tumor monocytes into malignant tumor macrophages associated with low survival rates in patients.
In this publication highlight, we review the use of LIBRA-seq to characterize monoclonal antibodies from a recovered SARS-CoV donor, expanding our understanding of cross-reactive antibodies for coronavirus.
Eric Peterson has long held an interest in the underpinnings of life, found enjoyment in science fiction, and taken a practical approach to career choices rooted in economics. He is not the guy who plotted his career path from start-to-finish; instead, he chose a career in the growing field of technology and was confident that there was a stable market for scientific professionals.
When scientists detect targets of interest with immunohistochemistry (IHC), antibody binding and substrate detection alone often produce a perplexing picture where the target lacks context. Luckily there’s a solution. Counterstaining IHC samples after enzymatic detection spatially orients the target within its surroundings, which can help guide researchers as they analyze their results.
In this publication highlight, we review a study examining the impact of macrophage-derived microparticles on the tumor microenvironment and their synergistic effect on anti-PD-1 antibody activity.
When it comes to selecting the substrate for your IHC application, you have variety and flexibility, and our focus is to help you make the right decision. This blog discusses different factors to consider—enzyme, sensitivity, color, method of visualization, and stability—when selecting the appropriate substrate (and, consequently, color) for your experiment.
When performing IHC, scientists aspire to reduce background or non-specific staining on the specimen. Explore how you can block the sources of non-specific signals increases the signal-to-noise ratio for optimal results.
When Courtney Young was a senior in high school, her 15 year old cousin was diagnosed with Duchenne muscular dystrophy (DMD). This diagnosis provided her with a strong motivation to pursue a future in science, which ultimately led to her interest in muscle biology and associated diseases. Since then, her interest has never faltered and she is now the CEO of gene therapy startup company MyoGene Bio, which focuses on the development of cutting edge genetic therapies for muscle diseases. For Courtney, this initiative continues to be personal, with the hope of someday being able to help her cousin who suffers from DMD, the most common form of muscular dystrophy.
Bioconjugation offers a way to chemically link two molecules to form a single hybrid, where at least one of the molecules in the partnership is a biomolecule. The resulting product retains the activity of each component, yet also gains novel functionality that is not possible with either molecule alone. In a recent webinar, Dr. Craig Pow, Director of Technical Services at Vector Laboratories provided an introduction to bioconjugation and its applications, as well as key factors to success.
Stay in the Loop
Join Our Online Community
The latest news, tips, and product releases delivered conveniently to your inbox.
We’re social scientists! Let’s connect.
Together we breakthroughTM
©Vector Laboratories, Inc. 2023 All Rights Reserved.