Let’s Talk Protein Glycosylation at Cancer Glyco-X
Vector Laboratories will be attending Cancer Glyco-X 2026 to discuss how the right tools reveal glyco-insights in cancer research.
Product Manager Shuhui Chen and Sr. Field Application Scientist Sabrina Mateos will be representing Vector Laboratories at the Van Andel Institute from May 5-6 and are looking forward to sharing new methods for spatially analyzing protein glycosylation.
Be sure to attend their poster presentation highlighting how Glysite™ Scout Glycan Screening Kits and Glysite™ Explorer in situ PLA Glycan Detection Kits make studying glycan modifications more accessible to cancer researchers.
Glycosylation & Glycobiology
Lectin-based reagents and tools to visualize protein glycosylation in situ for new insights into disease biology, biomarker discovery, and tumor microenvironments.
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Poster Presentation
Novel Tools for Spatial Profiling of Protein Glycosylation in Cancer Biology
Speakers
Shuhui Chen, Ph.D.
Product Manager
Sabrina Mateos, M.B.A.
Sr. Field Application Scientist
Abstract
Glycan modifications play critical roles in cell function in both healthy and diseased states, from controlling proliferation to modulating the immune response. Lectins are glycan-binding proteins that recognize specific glycan structures. Their glycan-specific nature makes them important tools to profile, characterize, and capture the complexity of glycans in biological systems.
To explore the complexity of glycan modifications, Vector Laboratories provides Glysite™ Scout Glycan Screening Kits, which are fully integrated kits for the detection of glycan expression in tissue sections. Our curated lectin selection enables the detection of the major glycan motifs including sialylation, fucosylation and galactosylation, for the evaluation of glycan distribution in a target specimen. Here, we established a standard workflow of lectin-integrated tissue immunoassays. Formalin-fixed, paraffin-embedded (FFPE) tissue sections were prepared from a selected panel of normal and cancerous tissues including colon, pancreas, breast, kidney, brain, and lung. Our lectin histochemical analysis revealed tissue-dependent glycopatterns, and our result was aligned with morphological changes observed in disease progression. We then utilized Glysite Explorer in situ PLA Glycan Detection Kit, a novel proximity-based detection technology, to investigate protein-specific glycosylation changes from healthy to diseased tissues. Our findings highlight distinct glycosylation patterns associated with pathological conditions, including cancer, underscoring the relevance of glycosylation in disease mechanisms.
In summary, Glysite™ Scout Glycan Screening Kits are easily plugged into day-to-day tissue immunoassays that allow comprehensive screening of N- and O-glycan profiles in various tissue sections. In addition to glycan expression, Glysite Explorer Kit can be used to explore the glycosylation changes of specific biomarkers in cancer tissues. Altogether, this new data will add to the growing understanding of the impact of protein glycosylation on cancer biology.
Featured Resource
See How Glycosylation Expands the Omics Landscape
Understanding cell biology requires more than measuring protein expression alone. Post-translational modifications like glycosylation add a critical layer of insight into disease mechanisms, biomarker discovery, and therapeutic development.
This infographic illustrates how glycosylation fits into the evolving omics landscape and why spatially resolving these modifications is key to advancing research.
