Tetrazine-PEG5-NHS Ester

Tetrazine-PEG5-NHS Ester is an amine-reactive labeling reagent often used for modification of proteins, peptides, or amine-modified oligonucleotides with tetrazine moiety. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10 fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG5) spacer arm.

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SKU: CCT-1143
CAS Number
1682653-80-0
Molecular Weight
604.61
Appearance
Red amorphous solid to red oil
Chemical Formula
C27H36N9O10
Purity
>95% (HPLC)
Unit Size
4 x 2 mg, 10 mg, 25 mg, 100 mg
Solubility
DMSO, DMF, DCM, THF, Chloroform
Storage Instructions
-20°C. Desiccate
Shipping Conditions
Ambient temperature
Shipping Instructions
Ambient temperature
Selected References
  1. Ingham, E. S., et al. (2020). Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation. Nat Commun, 11, 2102. [Nature Communications]