Biotin Picolyl Azide

Biotin Picolyl Azide is an advanced biotin probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site to boosted the efficiency of the CuAAC reaction resulting in a faster and more biocompatible CuAAC labeling. Up to 40-fold increase of signal intensity, compared to conventional azides was reported (see Selected References).

Price range: $176.00 through $1,227.00

Category: Biotin Azide Reagents

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SKU: CCT-1167

CAS Number N/A
Molecular Weight 622.74
Appearance Off-white to slightly orange amorphous solid
Chemical Formula C27H42N8O7S
Purity >95% (HPLC)
Unit Size 5 mg, 25 mg, 100 mg
Solubility DMSO, DMF
Storage Instructions -20°C. Desiccate
Shipping Conditions Ambient temperature
Shipping Instructions Ambient temperature

Selected References

Wood, T. M., et al. (2021). Optimization of Metabolic Oligosaccharide Engineering with Ac₄GalNAlk and Ac₄GlcNAlk by an Engineered Pyrophosphorylase. ACS Chem. Biol., [PubMed]
Banerjee, A.K.,et al. (2020). SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses. Cells., [Cell]
Gaebler, A.,et al. (2016). A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins. J. Lipid. Res., 57, 1934-47. [PubMed]
Jiang, H., et al. (2014). Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem.,, 25, 698-706. [PubMed]
Uttamapinant, C., et al. (2012). Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling. Angew. Chem. Int. Ed,., 51, 5852-56. [PubMed]