Tris (2-carboxyethyl) phosphine hydrochloride (TCEP)

Tris(2-carboxyethyl)phosphine hydrochloride (commonly known as TCEP or TCEP-HCl), product number QBD-10014, is a water-soluble reducing agent that cleaves disulfide bonds specifically, rapidly reducing them to thiols. TCEP has several advantages over disulfide reducing agents such as dithiothreitol (DTT) and β-mercaptoethanol. These advantages include water solubility, stability in water and non-phosphate aqueous buffers (allowing the preparation of stock solutions, except in aqueous buffers containing phosphate), ease of use, biocompatibility, high reaction specificity, irreversibility of the reaction, and very rapid and efficient reaction kinetics.

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SKU: QBD-10014
CAS Number
51805-45-9
Molecular Weight
286.65; single compound
Chemical Formula
C₉H₁₆CLO₆P
Purity
> 98%
Unit Size
1000mg, 5000mg, 25g, 100g
Solubility
water.
Storage Instructions
-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.
Shipping Instructions
Ambient