m-dPEG®₈-acid

m-dPEG®8-acid, product number QBD-10324, is a medium-length (26 atoms), methyl-capped, discrete chain length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule terminates in a propionic acid group. The terminal propionic acid moiety can be coupled directly to free amines using EDC or another carbodiimide. Alternatively, the reactive end can be functionalized as an active ester that can then be conjugated to free amines. N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), and 2,3,4,5,6-pentafluorophenol (PFP) typically are used for this functionalization.

m-dPEG®8-acid can modify amine-functionalized surfaces (carbon nanotubes, other nanoparticles, quantum dots, etc.) or free amines on biomolecules. When used to coat surfaces or modify biomolecules, m-dPEG®8-acid reduces, and often eliminates, non-specific binding and increases hydrophilicity. Please note that modification of surface amines on biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Price range: $192.00 through $437.00

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SKU: QBD-10324
CAS Number
1093647-41-6
Molecular Weight
412.47; single compound
Chemical Formula
C₁₈H₃₆O₁₀
Purity
> 97%
Unit Size
100 mg, 1000 mg
Solubility
Methylene chloride, Acetonitrile, DMAC or DMSO.
Spacers
dPEG® Spacer is 26 atoms and 29.8 Å
Storage Instructions
-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.
Shipping Instructions
Ambient