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m-dPEG®₈-acid (QBD-10324)

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Description

m-dPEG®8-acid, product number QBD-10324, is a medium-length (26 atoms), methyl-capped, discrete chain length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule terminates in a propionic acid group. The terminal propionic acid moiety can be coupled directly to free amines using EDC or another carbodiimide. Alternatively, the reactive end can be functionalized as an active ester that can then be conjugated to free amines. N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), and 2,3,4,5,6-pentafluorophenol (PFP) typically are used for this functionalization.

m-dPEG®8-acid can modify amine-functionalized surfaces (carbon nanotubes, other nanoparticles, quantum dots, etc.) or free amines on biomolecules. When used to coat surfaces or modify biomolecules, m-dPEG®8-acid reduces, and often eliminates, non-specific binding and increases hydrophilicity. Please note that modification of surface amines on biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight412.47; single compound
Chemical formulaC₁₈H₃₆O₁₀
CAS1093647-41-6
Purity> 97%
SpacersdPEG® Spacer is 26 atoms and 29.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Surface functionalization of magnetic iron oxide nanoparticles for MRI applications –effect of anchoring group and ligand exchange protocol. Eric D. Smolensky, Hee-Yun E. Park, Thelma S. Berquo and Valerie C. Pierre. Contrast Media Mol. Imaging Journal. 2010 6 (4), pp 189-199. August 2010. DOI:10.1002/cmmi.417.

Multivalent Benzamidine Molecules for Plasmin Inhibition: Effect of Valency and Linker Length. Tanmaye Nallan Chakravarthula, Dr. Ziqian Zeng, Prof. Nathan J. Alves. ChemMedChem, Volume 17, Issue 22, (2022), 09/16/2022, https://doi.org/10.1002/cmdc.202200364

Applicable patents and legal notices are available at legal notices.

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