F-ara-EdU (CCT-1403)

Description

F-ara-EdU is a probe for DNA synthesis that is less toxic compared to 5-ethynyl-2′-deoxyuridine (EdU) and BrdU. Ideally suited for metabolic DNA labeling experiments where long-term cell survival and/or deep-tissue imaging are desired. The alkyne handler can be used for subsequent ligation to azide-containing molecules through a highly efficient click chemistry reaction.

Specifications

Documents

Selected References

1. Raz, A. A., et al. (2021). Planarian stem cells specify fate yet retain potency during the cell cycle. Cell Stem Cell., 28 (7), 1307-1322.e5. [PubMed]
2. Neef, A.B., et al. (2011). Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides. PNAS,, 108, 20404-9. [PubMed]