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Bis-sulfone NHS Ester (CCT-1104)

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Description

Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.

The covalent, site-specific conjugation of PEG to a polyhistidine tag (His-tag) on a protein with bis-alkylating reagents was also reported in literature (see Selected References section).

Specifications

Unit Size1000 mg, 5 g
Molecular weight597.66
Chemical compositionC29H27NO9S2
CAS899452-51-8
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceGrey solid
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Selected References

 

Applicable patents and legal notices are available at legal notices.

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