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Bis-Maleimide amine,TFA salt (QBD-10232)

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Bis-Maleimide amine, TFA salt, product number QBD-10232, is a crosslinking product designed to bridge disulfide bonds. Built around a lysine core, maleimido-propanoate modifies both the α and ε amino groups of lysine. Diaminohexane converts the carboxylic acid of lysine to an amine (as a TFA salt). This is not a dPEG® product; however, it can react with the carboxylic acid termini of dPEG® products to form new products.

Description

Bis-Maleimide amine, TFA salt, product number QBD-10232, is a crosslinking product designed to bridge disulfide bonds. Built around a lysine core, maleimido-propanoate groups modify the α and ε amine of lysine. Diaminohexane converts the carboxylic acid of lysine to an amine (as a TFA salt). This is not a dPEG® product; however, it can react with the carboxylic acid termini of dPEG® products to form new products.

Bis-Maleimide amine, TFA salt, is designed to bridge disulfide bonds. The spacer length from maleimide reactive site through the α-amino group to the terminal amine-TFA salt is 17 atoms and 19.1 Å. The spacer length from the maleimide double bond through the ε-amino group to the terminal amine-TFA salt is 21 atoms and 19.6 Å.
Bis-Maleimide amine, TFA salt, is designed to bridge disulfide bonds. The spacer length from maleimide reactive site through the α-amino group to the terminal amine-TFA salt is 17 atoms and 19.1 Å. The spacer length from the maleimide double bond through the ε-amino group to the terminal amine-TFA salt is 21 atoms and 19.6 Å.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight660.64; single compound
Chemical formulaC₂₈H₃₉F₃N₆O₉
CAS1301738-40-8
Purity> 95%
SpacersSpacer is 17 and 21 atoms and 19.1 and 19.6 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
  2. Mono-PEGylated Dimeric Exendin-4 as High Receptor Binding and Long-Acting Conjugates for Type 2 Anti-Diabetes Therapeutics.Tae Hyung Kim, Hai Hua Jiang, Seulki Lee, Yu Seok Youn, Chan Woong Park,Youngro Byun, Xiaoyuan Chen, and Kang Choon Lee. Bioconjugate Chem. 2011, 22 (4), pp 625–632. March 14, 2011. DOI: 10.1021/bc100404x.
  3. Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators. Justin M. Scheer, Wendy Sandoval, J. Michael Elliott, Lily Shao, Elizabeth Luis, Sock-Cheng Lewin-Koh, Gabriele Schaefer, Richard Vandlen. PLOS ONE. 2012, 7 (12) e51817. December 20, 2012. DOI: 10.1371/journal.pone.0051817.

Applicable patents and legal notices are available at legal notices.

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