Dde Biotin Picolyl Azide

Dde Biotin Picolyl Azide is an azide-activated cleavable biotin probe that allows for efficient recovery of avidin-bound protein complexes in affinity-based assays. This reagent contains a biotin moiety linked to azide group through a spacer arm containing a hydrazine-cleavable Dde moiety. Under mild conditions (2% aqueous hydrazine), the Dde liner is cleaved, releasing the biotin tag and any avidin conjugate bound to it.

Price range: $102.00 through $787.00

Category: Biotin Azide Reagents

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SKU: CCT-1186

CAS Number 2055048-42-3
Molecular Weight 815.98
Appearance Oil to amorphous solid
Chemical Formula C38H57N9O9S
Molecular Weight Left Behind 220.24
Unit Size 1 mg, 5 mg, 25 mg
Solubility DMSO, DMF, THF, DCM, Chloroform
Storage Instructions -20°C.
Shipping Conditions Ambient temperature
Shipping Instructions Ambient temperature

Selected References

Howell, A. R., et al. (2021). α-Methylene-β-Lactone Scaffold for Developing Chemical Probes at the Two Ends of the Selectivity Spectrum. Chembiochem., 22 (3), 505-515. [PubMed]
Matthew E. G., et al. (2017). Comprehensive Mapping of O-GlcNAc Modification Sites Using a Chemically Cleavable Tag. Mol. Biosyst, 12: 1756–59. [PubMed]
Gertsik N., et al. (2017). Mapping the Binding Site of BMS-708163 on y-Secretase with Cleavable Photoprobes. Cell Chemical Biology, 32: 3-8. [PubMed]
Jiang, H., et al. (2014). Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem., 25: 698-706. [PubMed]
Yang Y., et al. (2013). Cleavable Trifunctional Biotin Reagents for Protein Labeling, Capture, and Release. Chem. Commun., 48: 5366-86. [PubMed]
Uttamapinant, C., et al. (2012). Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling. Angew. Chem. Int. Ed,. 51: 5852–56. [PubMed]