Heterobifunctional Amine & Thiol Reactive

Cross-Linkers and DSPE Linkers | Classical Cross-Linkers: Heterobifunctional Amine & Thiol Reactive

Heterobifunctional amine and thiol-reactive cross-linkers are specialized reagents designed to facilitate covalent bonding between two distinct functional groups—an amine (typically on a protein or antibody) and a thiol group (often present on peptides or cysteine residues). These cross-linkers contain two different reactive ends: one that targets primary amines and another that reacts specifically with thiol groups.

The versatility of these cross-linkers makes them ideal for creating stable conjugates in various applications, such as protein-protein interaction studies, immunoassays, and surface labeling of cells. By enabling the targeted attachment of molecules with different functional groups, heterobifunctional cross-linkers provide enhanced specificity and controlled conjugation for downstream detection and analysis.