Absolute Antibody, a Vector Laboratories company, was founded with the vision that recombinant antibodies should be accessible to all.

A leading provider of custom antibody sequencing, engineering, production, and purification services, we serve biotech innovators across therapeutic, diagnostic, and research applications. Our mission is to deliver engineered confidence—ensuring every antibody we produce is built on scientific rigor, transparency, and fit-for-purpose quality.

Antibody Engineering Expertise

Confidence engineered into every antibody.

Successful production of 200+ different antibody formats
Specialization in complex constructs including bispecifics, scFvs, and fragments
Collaborative approach to develop the antibody best suited to your needs

Tailored Solutions

Every process is tailored to your molecule—not the other way around

Customized workflow, from design to purification, based on the unique characteristics of each antibody
45+ purification routes across a dozen platforms to elicit highly pure antibodies

Rigorous Quality Controls

Quality built in, not bolted on.

Workflows designed with quality in mind, not just QC at the end
Built in checks throughout the process to go beyond “good enough”
SEC and CE-SDS included as standard practice

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Engineered recombinant antibodies developed for our reagents catalog

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Hybridomas sequenced

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Successful antibody humanization projects

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Different antibody formats produced

Custom Antibody Services: Sequencing

It starts with a sequence.

Knowing your hybridoma or antibody protein sequence is crucial for the security and continuation of your antibody production. Our antibody sequencing services include Next Generation Sequencing of hybridoma cells and de novo sequencing of purified antibody protein. Sequencing can be performed as a stand-alone activity, or as the first step toward antibody engineering and transient serum-free expression. Whether it is a hybridoma or purified monoclonal antibody protein, Absolute Antibody offers industry-leading sequencing services to help safeguard your invaluable antibody.

Why Sequence Your Antibodies?

Protect against loss, contamination or genetic drift
Secure your supply chain
Enable antibody engineering and recombinant production
Patent your antibody

Antibody Protein Sequencing Service

Sequence from purified monoclonal antibody when hybridoma is not available
Combines mass spectrometry with high accuracy de novo peptide sequencing and recombinant expression

Protein Sequencing Services

Hybridoma Sequencing Service

Novel NGS approach to high-throughput sequencing
Identifies all heavy chain and light chain sequences and quantifies their relative abundance
Compatible with any species and isotype

Hybridoma Sequencing Services

custom antibody services - hybridoma sequencing method — Our hybridoma sequencing method – The mRNA transcriptome is obtained from the hybridoma, and random hexamers are used to generate a cDNA library. This is fragmented and undergoes paired-end sequencing. The sequencing reads are assembled into contigs, from which antibody transcripts are identified based on homology.

Custom Antibody Services: Engineering

Engineered Confidence. Built Around Your Molecule.

Antibody engineering allows for the modification of antibodies to build molecules better suited for your application. At Absolute Antibody, we utilize a proprietary cloning system that enables the rapid reformatting of antibodies into almost any format. From isotype and species switching to humanization and multispecifics, we engineer confidence into every step.

Explore our royalty-free antibody engineering capabilities.

Isotype
Switching Species
Switching Fragments Fc Silencing Humanization Multispecifics

Periodic Table of Antibodies

antibodies periodic table 2048x1742 1 — The Periodic Table of Antibodies showcases the wide assortment of custom antibodies we have produced. These novel antibody formats demonstrate the lengths scientists are going to combine protein engineering with biology to generate efficacious drugs. From standard IgGs to antibody fragments, multispecifics, and Fc fusion proteins, these new formats help tailor binding and half-life to specific biological settings. Every antibody depicted in the table has been manufactured in- house using our proprietary cloning system.

Explore 180+ antibody formats in our interactive Periodic Table of Antibodies

Custom Antibody Services: Production

Scalable expression tailored to your molecule.

Absolute Antibody’s expression platforms rapidly produce high-quality, animal-free recombinant antibodies in HEK or CHO cells. By utilizing a serum-free mammalian transient expression system, our production service offers a faster, more affordable alternative to stable cell line generation. This robust platform has proven success in manufacturing recombinant antibodies in any species, isotype, or format with high purity and low endotoxin levels.

Scalability matters, which is why we offer a microgram-to-gram range of expression capabilities. From small-scale production, perfect for lead discovery candidate selection, to large-scale production, our expression services are flexible to your needs.

HEXpress™

HEK Antibody Production

CHXpress™

CHO Antibody Production

FleXpress™

Antibody Production

FinessePress™

High-Throughput Antibody Production

Custom Antibody Services