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Propargyl-dPEG®₁-NHS ester (QBD-10511)

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Description

Propargyl-dPEG®1-NHS ester, product number QBD-10511, is a crosslinking click chemistry reagent. The alkynyl end of the molecule reacts with azides via copper(I) or ruthenium catalysis to form 1,3- or 1,5-dipolar cycloaddition products, respectively. The NHS ester end of the molecule reacts with primary and secondary amines to form stable amide bonds.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight225.20; single compound
Chemical formulaC₁₀H₁₁NO₅
CAS1174157-65-3
Purity> 98%
SpacersdPEG® Spacer is 7 atoms and 7.2 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC, DMSO
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Covalent Attachment of Lipid Cesicles to a Fluid-Supported BIlayer Allows Observation of DNA-Mediated Vesicle Interactions, Bettina van Lengerich, Robert J. Rawle, and Steven G. Boxer, Langmuir, 2010, 26 (11), pp 8666–8672, February 24, 2010. DOI: 10.1021/la904822f.

An Effective Targeted Nanoglobular Manganese(II) Chelate Conjugate for Magnetic Resonance Molecular Imaging of Tumor Extracellular Matrix, Mingqian Tan, Xueming Wu, Eun-Kee Jeong, Qianjin Chen, Dennis L. Parker, and Zheng-Rong Lu, Mol. Pharmaceutics, 2010, 7 (4), pp 936–943 May 19, 2010. DOI: 10.1021/mp100054m.

Illuminating Epidermal Growth Factor Receptor Densities on Filopodia through Plasmon Coupling. Jing Wang, Svetlana V. Boriskina, Hongyun Wang, and Bjorn M. Reinhard. ACS Nano. 2011, 5 (8), pp 6619–6628. July 17, 2011. DOI: 10.1021/nn202055b.

Monitoring the Size and Lateral Dynamics of ErbB1 Enriched Membrane Domains through Live Cell Plasmon Coupling Microscopy. Guoxin Rong, Bjorn M. Reinhard. PLoS ONE. 2012, 7 (3) e34175. March 28, 2012. DOI:10.1371/journal.pone.0034175.

Monitoring the Size and Lateral Dynamics of ErbB1 Enriched Membrane Domains through Live Cell Plasmon Coupling Microscopy. Guoxin Rong, Bjorn M. Reinhard. PLoS ONE. 2012, 7 (3) e34175. March 28, 2012. DOI:10.1371/journal.pone.0034175.

An Intein-Mediated Site-Specific Click Conjugation Strategy for Improved Tumor Targeting of Nanoparticle Systems. Drew R. Elias, Dr. Zhiliang Cheng, and Prof. Andrew Tsourkas. Small 2010 6 (21) pp 2460–2468 November 5, 2010. DOI:10.1002/smll.201001095.

Peptide-Targeted Nanoglobular Gd-DOTA Monoamide Conjugates for Magnetic Resonance Cancer Molecular Imaging. Mingqian Tan, Xueming Wu, Eun-Kee Jeong, Qianjin Chen, and Zheng-Rong Lu. Biomacromolecules 2010 11 (3) pp 754–761 March 8, 2010. DOI:10.1021/bm901352v.

Nanoconjugation: a materials approach to enhance epidermal growth factor induced apoptosis. Linxi Wu, Xinwei Yu, Amin Feizpour and Björn M. Reinhard. Biomaterials Science. 2013, (www.rsc.org/biomaterialsscience). September 23,2013. DOI: 10.1039/c3bm60142k.

Prodrug Strategy for PSMA-Targeted Delivery of TGX-221 to Prostate Cancer Cells. Yunqi Zhao, Shaofeng Duan, Xing Zeng, Chunjing Liu, Neal M. Davies, Benyi Li, and M. Laird Forrest. Mol. Pharmaceutics. 2012, 9 (6) pp 1705–1716. April 11, 2012. DOI: 10.1021/mp3000309.

Applicable patents and legal notices are available at legal notices.

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