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m-dPEG®₂-acid (QBD-10326)



m-dPEG®2-acid, product number QBD-10326, is a very short, methyl-capped, discrete chain length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule terminates as a propionic acid group. This group can be directly coupled to free amines on biomolecules and surfaces using EDC or another carbodiimide. Alternately, the reactive end can be functionalized with N-hydroxysuccinimide (NHS); 2,3,5,6-tetrafluorophenol (TFP); 2,3,4,5,6-pentafluorophenol (PFP); or some other activating agent for reaction with amines.

m-dPEG®2-acid can modify amine-functionalized surfaces (carbon nanotubes, other nanoparticles, quantum dots, etc.) or free amines on biomolecules (e.g., peptides and proteins). Coating surfaces or biomolecules with m-dPEG®2-acid can reduce or eliminate non-specific binding and increase hydrophilicity. Please note that modification of surface amines on biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.


Unit Size100 mg, 1000 mg
Molecular Weight148.16; single compound
Chemical formulaC₆H₁₂O₄
Purity> 98%
SpacersdPEG® Spacer is 8 atoms and 8.5 Å
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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