Fmoc-N-amido-dPEG®₁₂-acid (QBD-10283)

Description

Fmoc-N-amido-dPEG®12-acid, product number QBD-10283, is one of a broad line of products designed for use in peptide synthesis. The medium-length (40 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®12 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10283 permits our customers to insert a medium-length (40 atoms) dPEG® into a peptide chain using familiar Fmoc chemistry. The product works equally well in solid phase and solution phase synthetic processes. The dPEG® can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible spacer between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Documents

References

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Influence of Defined Hydrophilic Blocks within Oligoaminoamide Copolymers: Compaction versus Sheilding of pDNA Nanoparticles. Stephan Morys, Ana Krhac Levacic, Sarah Urnauer, Susanne Kempter, Sarah Kern, Joachim O Radler, Christine Spitzweg, Ulrich Lachelt, and Ernst Wagner. Polymers. 2017, 9 (4) pp 1-20. April 19, 2017. DOI: 10.3390/polym9040142.

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Near-infrared quantum dots labelled with a tumor selective tetrabranched peptide for in vivo imaging. Jlenia Brunetti, Giulia Riolo, Mariangela Gentile, Andrea Bernini, Eugenio Paccagnini, Chiara Falciani, Luisa Lozzi, Silvia Scali, Lorenzo Depau, Alessandro Pini, Pietro Lupetti, and Luisa Bracci. Journal of Nanobiotechnology. 2018, 16 (21) pp. 1-10. March 3, 2018. DOI: 10.1186/s12951-018-0346-1.

Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors. Robert Pola ,Eliška Böhmová ,Marcela Filipová,Michal Pechar,Jan Pankrác, David Větvička, Tomáš Olejár, Martina Kabešová, Pavla Poučková, Luděk Šefc, Michal Zábrodský, Olga Janoušková, Jan Bouček, and Tomáš Etrych. Pharmaceutics 2020, 12(1), 31; January 1, 2020. https://doi.org/10.3390/pharmaceutics12010031

Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length. Eliška Böhmová ,Robert Pola, Michal Pechar, Jozef Parnica, Daniela Machová, Olga Janoušková and Tomáš Etrych. Pharmaceutics 2020, 12(1), 59; January 10, 2020. https://doi.org/10.3390/pharmaceutics12010059

A Novel Bivalent Mannosylated Targeting Ligand Displayed on Nanoparticles Selectively Targets Anti-Inflammatory M2 Macrophages. Peiming Chen, Xiaoping Zhang, Alessandro Venosa, In Heon Lee, Daniel Myers, Jennifer A. Holloway, Robert K. Prud’homme, Dayuan Gao, Zoltan Szekely, Jeffery D. Laskin, Debra L. Laskin, and Patrick J. Sinko. Pharmaceutics 2020, 12(3), 243. March 8, 2020. DOI: 10.3390/pharmaceutics12030243

A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment. Jlenia Brunetti, Sara Piantini, Marco Fragai, Silvia Scali, Giulia Cipriani, Lorenzo Depau, Alessandro Pini, Chiara Falciani, Stefano Menichetti and Luisa Bracci. Molecules 2020, 25(5), 1088; February 28, 2020. DOI: 10.3390/molecules25051088

Efficient capture of circulating tumor cells with low molecular weight folate receptor-specific ligands. Yingwen Hu, Danyang Chen, John V Napoleon, Madduri Srinivasarao, Sunil Singhal, Cagri A Savran, Philip S Low. Scientific Reports. 2022. May 20, 2022. https://doi.org/10.1038/s41598-022-12118-3