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Desthiobiotin Alkyne (CCT-1109)

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Description

Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin.

Specifications

Unit Size5 mg, 25 mg, 100 mg
Molecular weight427.23
Chemical compositionC21H37N3O6
CAS1951424-89-7
SolubilityDMSO, DMF
Purity>95% (HPLC)
AppearanceColorless to slightly yellow oil
Storage Conditions-20°C
Shipping ConditionsAmbient temperature

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