CBZ-N-amido-dPEG®36-acid, product number QBD-10906, is a benzyl carbamate (Cbz) N-protected amino-dPEG®-acid that provides a long (111 atoms, 132.7 Å), single molecular weight discrete PEG (dPEG®) spacer. It can be used in peptide synthesis to modify the side chain of lysine and in other forms of supramolecular construction. The Cbz protecting group is stable to acidic and basic conditions and is most easily removed using palladium black or palladium on carbon with hydrogen. This makes Cbz removal orthogonal to most other peptide synthesis deprotection reactions.
CBZ-N-amido-dPEG®36-acid works well in solution-phase synthesis. Carbodiimide activation, with or without an acylating agent, permits conjugation of the acid terminus of the dPEG® product to free amines. Other synthetic processes (e.g., surface modification, supramolecular construction) requiring the attachment or insertion of a medium-length PEG linker or spacer can employ CBZ-N-amido-dPEG®36-acid profitably also.
| Unit Size | 100mg, 1000mg |
|---|---|
| Molecular Weight | 1809.12; single compound |
| Chemical formula | C₈₃H₁₅₇NO₄₀ |
| CAS | 1334177-88-6 |
| Purity | > 98% |
| Spacers | dPEG® Spacer is 111 atoms and 132.7 Å |
| Shipping | Ambient |
| Typical solubility properties (for additional information contact Customer Support) | Methylene chloride, DMAC or DMSO or water. |
| Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
Applicable patents and legal notices are available at legal notices.
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