Biotin-PEG4-DBCO (CCT-A105)


A biotin probe for copper-free click chemistry reaction, Biotin-PEG4-DBCO reacts with azides to form a stable triazole and does not require Cu-catalyst or elevated temperatures. Often a reagent of choice in live cell surface glycans and lipids studies where the presence of cytotoxic copper catalyst is not acceptable. In application where the presence of copper is a concern Biotin-PEG4-DBCO is an ideal alternative to copper requiring biotin-alkynes.


Unit Size5 mg, 10 mg, 25 mg, 100 mg
Molecular weight749.92
Chemical compositionC39H51N5O8S
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceWhite to grey amorphous solid
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Selected References

  1. Bierbach, U., et al. (2021). DNA Adduct Detection after Post-Labeling Technique with PCR Amplification (DNA-ADAPT-qPCR) Identifies the Pre-ribosomal RNA Gene as a Direct Target of Platinum-Acridine Anticancer Agents. Chemistry.27 (59), 14681-14689. [PubMed]
  2. Pratt Matthew R., et al. (2020). Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins. Frontiers in Chemistry, 8, 318. [Frontiers in Chemistry]
  3. Bernardim, B., et al. (2020). Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling Bioconjugate Chem.31 (6), 1604-10. [PubMed]

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