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Azido-PEG4-NHS Ester (CCT-AZ103)

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Description

Azido-PEG4-NHS Ester is a labeling reagent that can be used to modify primary amine groups (e.g., a side chain of lysine residues or aminosilane-coated surfaces) with an azido group via a stable amide bond. The azide (N3) group reacts with terminal alkynes via CuAAC, strained cyclooctynes (e.g. DBCO or BCN compounds) via Cu-free click reaction or with phosphine-labeled molecules by a mechanism known as Staudinger chemistry, enabling efficient and specific conjugation of derivatized molecules in biological samples.

Specifications

Unit Size25 mg, 100 mg, 1000 mg
Molecular weight388.37
Chemical compositionC15H24N4O8
CAS944251-24-5
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceColorless to slightly yellow oil
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Selected References

  1. Hu, Y., Glazier, R., et al. (2021). DNA-based microparticle tension sensors (µTS) for measuring cell mechanics in non-planar geometries and for high-throughput quantification. Angew Chem Int Ed Engl., Online ahead of print. [PubMed]
  2. Bazrafshan, A. et al. (2021). DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second. ACS Publications, Online ahead of print. [PubMed]
  3. Bazrafshan, A., et al. (2020). Tunable DNA Origami Motors Translocate Ballistically Over μm Distances at nm/s Speeds. Angew. Chem. Int. Ed.59(24), 9514-21. [PubMed]

Applicable patents and legal notices are available at legal notices.

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