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9AzNue5Ac (CCT-1534)

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Description

Metabolic labeling of glycans with unnatural sialic acid analogues has emerged as an invaluable tool for studying sialic acid biology. It has been showed that 9-azido-9-deoxy-N-acetylneuraminic acid (9AzNeu5Ac), a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide, could be metabolized and incorporated into sialoglycans in living cells and mice. The incorporated sialic acid analogue, 9AzNeu5Ac, enable visualization the cell-surface sialoglycans and glycoproteomic profiling by click-labeling with fluorophores and affinity tags, respectively.

Specifications

Unit Size5 mg, 25 mg, 100 mg
Molecular weight334.28
Chemical compositionC11H18N4O8
CAS76487-51-9
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity≥95% (HPLC)
AppearanceSlightly grey amorphous solid
Storage Conditions-20°C.
Shipping ConditionsAmbient temperature

Selected References

  1. Cheng, B., et al. (2019). 9-Azido Analogues of Three Sialic Acid Forms for Metabolic Remodeling of Cell-Surface Sialoglycans. ACS Chem Biol. 14(10), 2141-7 [PubMed]
  2. Zhang, C., et al. (2016). In vivo metabolic labeling of sialoglycans in the mouse brain by using a liposome-assisted bioorthogonal reporter strategy. Proc Natl Acad Sci U S A.113 (19), 5173-8. [PubMed]
  3. Xie, R., et al. (2012). Cell-selective metabolic glycan labeling based on ligand-targeted liposomes. J. Am. Chem. Soc., 134(24), 9914-7. [ACSPublications]

Applicable patents and legal notices are available at legal notices.

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