Vector Labs is closed to observe Juneteenth (US Holiday) on Wednesday, June 19th.
We will be back in the office on Thursday. We will respond to emails upon our return. Have a wonderful day.

6-azido-6-deoxy-N-acetyl-glucosamine triacylated (Ac3-6AzGlcNAc) (CCT-1258)

[text-backorder]

Description

6-azido-6-deoxy-N-acetyl-glucosamine triacylated (Ac36AzGlcNAc) is an azide-containing, specific metabolic chemical reporter for O-GlcNAcylated proteins. Notably, 6AzGlcNAc cannot be biosynthetically transformed into the corresponding UDP sugar-donor by the canonical salvage-pathway that requires phosphorylation at the 6-hydroxyl. In vitro experiments showed that 6AzGlcNAc can bypass this roadblock through direct phosphorylation of its 1-hydroxyl by the enzyme phosphoacetylglucosamine mutase (AGM1). The azide-modified protein is detected with either fluorescent alkynes or biotin alkyne. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.

Specifications

Unit Size5 mg, 25 mg, 100 mg
Molecular weight372.33
Chemical compositionC14H20N4O8
CASN/A
SolubilityDMSO, DMF, DCM, THF, Chloroform
AppearanceWhite to grey amorphous solid
Storage Conditions-20°C.
Shipping ConditionsAmbient temperature

Applicable patents and legal notices are available at legal notices.

How do I Request a Quote?

To request a quote for products:

  1.  Log in to VectorLabs.com
  2.  Add the items you wish to quote to the cart;
  3.  View your cart;
  4.  Click on the “Request a Quote” button found below the items in your cart;
  5.  Download your quote