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Tris (2-carboxyethyl) phosphine hydrochloride (TCEP) (QBD-10014)



Tris(2-carboxyethyl)phosphine hydrochloride (commonly known as TCEP or TCEP-HCl), product number QBD-10014, is a water-soluble reducing agent that cleaves disulfide bonds specifically, rapidly reducing them to thiols. TCEP has several advantages over disulfide reducing agents such as dithiothreitol (DTT) and β-mercaptoethanol. These advantages include water solubility, stability in water and non-phosphate aqueous buffers (allowing the preparation of stock solutions, except in aqueous buffers containing phosphate), ease of use, biocompatibility, high reaction specificity, irreversibility of the reaction, and very rapid and efficient reaction kinetics.


Unit Size1000mg, 5000mg, 25g, 100g
Molecular Weight286.65; single compound
Chemical formulaC₉H₁₆CLO₆P
Purity> 98%
Typical solubility properties (for additional information contact Customer Support)water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


  1. Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); pp. 95-97 (protocol), 654.

  2. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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