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Desthiobiotin NHS Ester (CCT-1201)

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Description

Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015 M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin.

Specifications

Unit Size100 mg, 500 mg, 1000 mg
Molecular weight311.34
Chemical compositionC14H21N3O5
CAS80750-24-9
SolubilityDMSO, DMF
Purity>95%
AppearanceWhite solid
Storage Conditions-20°C
Shipping ConditionsAmbient temperature

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