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Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin.
Unit Size | 5 gm, 25 mg, 100 mg |
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Molecular weight | 414.50 |
Chemical composition | C18H34N6O5 |
CAS | 1306615-47-3 |
Solubility | DMSO, DMF |
Purity | >95% (HPLC) |
Appearance | Colorless to slightly yellow oil |
Storage Conditions | -20°C. Desiccate |
Shipping Conditions | Ambient temperature |
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