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Desthiobiotin Azide (CCT-1107)

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Description

Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin.

Specifications

Unit Size5 gm, 25 mg, 100 mg
Molecular weight414.50
Chemical compositionC18H34N6O5
CAS1306615-47-3
SolubilityDMSO, DMF
Purity>95% (HPLC)
AppearanceColorless to slightly yellow oil
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Selected References

  1. David, L. L., et al. (2021). Chemical Proteomics Approach for Profiling the NAD Interactome. J Am Chem Soc.143 (18), 6787-6791. [PubMed]
  2. Howell, A. R., et al. (2021). α-Methylene-β-Lactone Scaffold for Developing Chemical Probes at the Two Ends of the Selectivity Spectrum. Chembiochem.22 (3), 505-515. [PubMed]

Applicable patents and legal notices are available at legal notices.

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